Once the unit is connected to an AC power source and your computer is switched on:

1. Connect a USB 2.0 Type-B or Thunderbolt™ 3 cable to the corresponding ports on the Orion Studio Synergy Core and your computer.


  • The unit will automatically detect the connection type upon the initial startup, but not on subsequent starts. Manually set the connection type from ‘Comms. Interface’ in the System Menu every time you switch between Thunderbolt™ and USB connections.
  • After the initial setup, it is possible to keep both Thunderbolt™ and USB connections to your computer and switch between them from ‘Comms. Interface’ in the System Menu.
  • USB 2 connection supports up to 24 I/O audio channels. Thunderbolt™ connection supports up to 32 I/O audio channels.

2. Visit www.antelopeaudio.com and log-in or create a customer account (if you don’t have one). 

3. Download and install the latest Antelope Audio Launcher and Driver for your operating system (Windows 10 / macOS 10.12 or later) from the ‘Downloads’ section of the Orion Studio Synergy Core website.

Note: For Thunderbolt™ connection on Windows, download and install the latest Antelope Audio Windows Thunderbolt™ driver.

4. Open Antelope Launcher and make sure your Orion Studio Synergy Core is running the latest firmware and Control Panel versions.

Note: If your device isn’t recognized by Antelope Launcher, you can have a look at this video.

5. Launch the Orion Studio Synergy Core Control Panel from the Antelope Launcher and follow the device activation procedure.

Note: Bypass any security prompts from your operating system, e.g. Windows Defender Firewall and macOS alerts.

6. Connect your analog and digital equipment of choice to the Orion Studio Synergy Core.

7. Launch your preferred DAW and:

  • Choose the Orion Studio Synergy Core as your main input and output device.
  • Make sure your DAW and operating system sample rates match the device sample rate.

Need any help?

Visit the Antelope Audio Customer Support page, choose your device and go from there.

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Configuring for Windows 10

Windows 10 needs a few tweaks to get everything up and running:

1. Enter the ‘Sounds’ options window from the Control Panel or right-click the speaker icon in the system tray and choose ‘Sound’.

2. Enter the ‘Playback’ tab and make sure the Orion Studio Synergy Core is set as the default playback device. Choose the device and click ‘Properties’.

3. Enter the ‘Supported Formats’ tab and place checkmarks next to all the available sample rates.

4. Enter the ‘Enhancements’ tab and make sure all enhancements are disabled.

5. Enter the ‘Advanced’ tab and choose any of the available “2 channel, 24-bit” modes. Click ‘OK’ to close the window.

6. Enter the ‘Recording’ tab and make sure the Orion Studio Synergy Core is set as the default recording device. Click ‘OK’ to close the window.


  • If you are experiencing interruptions or failure when using your DAW and trying to playback audio from your OS at the same time, make sure that the device sample rate matches the one of your DAW session.
  • You can disable the device and enable it again from the ‘Playback’ tab to refresh the driver. This will be similar to disconnecting and re-connecting your device, which makes Windows reset the playback configuration of the applications you are using.
  • In some cases, disabling the ‘Exclusive mode’ functionality from the ‘Advanced’ tab in ‘Playback’ Properties might help when running multiple playback applications at the same time.
  • Disabling the 32kHz sample rate isn’t mandatory, but it might help in general.

Further Reading

Antelope Audio Knowledge Base - Windows 10 Optimization

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Configuring for macOS Mojave 10.14 (or later)

The new security settings introduced in macOS Mojave 10.14 may result in no input signal reaching your DAW, despite having everything set up correctly.

These steps apply when you are using the Orion Studio Synergy Core in a DAW for the first time:

1. Launch your DAW and choose Orion Studio Synergy Core as the input device. The following dialog box will appear (if using Ableton Live 10 Suite, for example):

3. Click 'OK' and your DAW should function normally.

However, if the events above did not occur for some reason, or you are using multiple DAWs, you must do a manual tweak for each in 'Security & Privacy' settings:

1. Click the 'Apple' symbol and choose 'System Preferences'. Head to the 'Security & Privacy' settings menu.

2. Click the 'Privacy' tab. In the column on the left, choose ‘Microphone’. Make sure there's a checkmark next to any DAW you want to use.

Note: You may have to click the padlock symbol in the bottom left corner and enter your password to make changes.

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